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Yeast prions: Paramutation at the protein level?

Mick F Tuite1

  • 1Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.

Seminars in Cell & Developmental Biology
|September 20, 2015
PubMed
Summary
This summary is machine-generated.

Yeast prions, proteins that change shape, can be passed down through generations. This prion-induced change impacts yeast traits, adaptation, and evolution.

Keywords:
AmyloidConformational conversionEpigenetic inheritancePrion variantsPrionsPropagonsProtein conformationSaccharomyces cerevisiaeTranscription factorsYeast

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Area of Science:

  • Molecular biology
  • Epigenetics
  • Yeast genetics

Background:

  • Prions are proteins capable of adopting a self-propagating misfolded conformation.
  • In yeast (Saccharomyces cerevisiae), prions can mediate trans-generational epigenetic inheritance.
  • Prion formation can lead to both loss-of-function and gain-of-function phenotypes.

Purpose of the Study:

  • To explore the role of prions in yeast Saccharomyces cerevisiae.
  • To understand how prionogenesis influences host phenotype and adaptation.
  • To investigate the mechanisms of heritable protein conformational changes.

Main Methods:

  • Analysis of prion structures and functions in yeast.
  • Studying the impact of prionogenesis on yeast phenotype.
  • Comparing prionogenesis with paramutation.

Main Results:

  • Prions can be structurally and functionally diverse in yeast.
  • Prionogenesis affects host phenotype, enabling short-term adaptation and evolution.
  • Prion formation involves mitotically and meiotically heritable changes in protein conformation.

Conclusions:

  • Prions in Saccharomyces cerevisiae serve as a model for trans-generational epigenetic inheritance.
  • Prionogenesis significantly impacts yeast adaptation and evolution by altering protein function.
  • Prion formation is a heritable change in protein conformation mediated by protein interactions.