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Updated: Apr 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antimicrobial stewardship policy: time to revisit the strategy?
Abstract:
Recent data indicate that both the overall numbers of antibiotic prescription and the frequency of multidrug-resistant bacteria are increasing significantly. These threatening features are observed, despite national antimicrobial stewardship (AMS) policies aimed at decreasing antibiotic use. AMS should also focus on the initial steps leading to antibiotic prescription. Physicians and their patients should benefit from the structured clinical pathways, the latter being adapted to regional epidemiological data and resources. Continuous evaluation of these predefined clinical paths through a computerized medical dashboard will allow a critical review and finally the optimization of medical practices. These innovative behavioural approaches for clinicians will supply precise information on the relationship among the diagnosis, therapeutics and outcome. This changing environment will carry out the adapted therapeutic procedures, and appropriate antibiotic use will inherently improve.
Insights
Antimicrobial stewardship (AMS) policies need to address initial prescription steps. Structured clinical pathways and medical dashboards can optimize antibiotic use and combat rising multidrug-resistant bacteria.
Area of Science:
- Infectious Diseases
- Public Health
- Clinical Pharmacy
Background:
- Increasing antibiotic prescriptions and multidrug-resistant bacteria pose significant global health threats.
- Current antimicrobial stewardship (AMS) policies aim to reduce antibiotic use but require refinement.
- There's a need to focus AMS efforts on the crucial initial stages of antibiotic prescription.
Purpose of the Study:
- To propose enhanced strategies for antimicrobial stewardship (AMS).
- To highlight the importance of structured clinical pathways in guiding antibiotic prescriptions.
- To emphasize the role of continuous evaluation via medical dashboards for optimizing antibiotic use.
Main Methods:
- Development of structured clinical pathways tailored to regional epidemiology and resources.
- Implementation of a computerized medical dashboard for continuous evaluation of clinical practices.
- Focus on innovative behavioral approaches for clinicians to improve diagnosis-treatment-outcome relationships.
Main Results:
- Structured clinical pathways provide physicians and patients with clear guidance.
- Medical dashboards enable critical review and optimization of prescribing practices.
- Behavioral interventions offer precise data linking diagnosis, therapeutics, and patient outcomes.
Conclusions:
- Optimizing antibiotic use requires a focus on the entire prescribing process, from initial diagnosis to treatment outcome.
- Structured clinical pathways and data-driven evaluation are essential for effective antimicrobial stewardship.
- These approaches are crucial for adapting therapeutic procedures and improving antibiotic use in the face of rising resistance.
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