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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Urinary Leukotriene E4 Level in Non-Allergic Thai Young Children

Phinidda Cha-umphol, Paskorn Sritipsukho, Sirikul Manochantr

    Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
    |September 22, 2015
    PubMed

    Insights

    Urinary leukotriene E4 (uLTE4) levels were established in non-allergic Thai children. Concentrations were higher in younger children, providing crucial reference data for pediatric respiratory allergy research.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Allergy and Immunology

    Background:

    • Urinary leukotriene E4 (uLTE4) concentration reflects systemic leukotriene synthesis.
    • Elevated uLTE4 levels are observed in respiratory allergic diseases.
    • Establishing normal uLTE4 levels in non-allergic children is essential for comparative research.

    Purpose of the Study:

    • To determine the reference values for urinary leukotriene E4 (uLTE4) in non-allergic Thai children.
    • To utilize the competitive enzyme-linked immunosorbent assay (ELISA) technique for accurate measurement.

    Main Methods:

    • Inclusion of healthy Thai children aged 6 months to 5 years undergoing elective surgery.
    • Exclusion of participants with acute illnesses, respiratory allergies (allergic rhinitis, asthma), or chronic diseases.
    • Collection of morning urine samples for competitive ELISA analysis of uLTE4.

    Main Results:

    • Analyzed 36 urine samples from children aged 6-60 months (26 boys, 10 girls).
    • Mean uLTE4 concentration was 619.73 ± 701.32 pg/ml; adjusted for creatinine, it was 1,328 ± 788.54 pg/mg creatinine.
    • Mean uLTE4 levels adjusted for creatinine showed higher concentrations in younger age groups (6-18 months).

    Conclusions:

    • Presented age-specific reference concentrations for uLTE4 and uLTE4 per creatinine in young Thai children without respiratory disease.
    • Observed elevated uLTE4 concentrations in the younger age cohort.
    • Provides baseline data for pediatric allergy and respiratory research.
    Abstract

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