Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How Hydrotropy Explains the Influence of Dissolved Gases on the Properties of Aqueous Salt Solutions.

The journal of physical chemistry. B·2026
Same author

Ferrite-based materials for anticorrosion: comparative study of ZnFe<sub>2</sub>O<sub>4</sub>, CuFe<sub>2</sub>O<sub>4</sub>, and SrFe<sub>12</sub>O<sub>19</sub>.

RSC advances·2026
Same author

Combined Experimental and Computational Study on the Structure-Property Relationships of Mono- and Dicationic Imidazolium Ionic Liquids for CO<sub>2</sub> Capture.

The journal of physical chemistry. B·2026
Same author

Competitive solvation of <i>p</i>-nitroaniline by water, diethyl sulfoxide, <i>n</i>-heptane, and AOT micelles.

Physical chemistry chemical physics : PCCP·2026
Same author

Atomic-Scale Insights into Phosphorene-Ionic Liquid Interface with Ab Initio Molecular Dynamics.

ACS physical chemistry Au·2026
Same author

Investigation of a novel urethane-inspired CO<sub>2</sub> chemisorbent: structure modifications and activation barriers.

Physical chemistry chemical physics : PCCP·2025

Related Experiment Video

Updated: Apr 3, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

30.3K

Polypeptide A9K at nanoscale carbon: a simulation study.

Vitaly V Chaban1, Andre Arruda, Eudes Eterno Fileti

  • 1Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, 12231-280, São José dos Campos, SP, Brazil. fileti@gmail.com.

Physical Chemistry Chemical Physics : PCCP
|September 22, 2015
PubMed
Summary

Surfactant-like peptides (A9K) favorably bind to nanoscale carbons like graphene and ultrashort carbon nanotubes (USCNTs). Encapsulation within USCNTs is especially favorable, suggesting potential for advanced biomaterials and drug delivery.

More Related Videos

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

7.2K
Studying Soft-matter and Biological Systems over a Wide Length-scale from Nanometer and Micrometer Sizes at the Small-angle Neutron Diffractometer KWS-2
11:27

Studying Soft-matter and Biological Systems over a Wide Length-scale from Nanometer and Micrometer Sizes at the Small-angle Neutron Diffractometer KWS-2

Published on: December 8, 2016

12.9K

Related Experiment Videos

Last Updated: Apr 3, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

30.3K
OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

7.2K
Studying Soft-matter and Biological Systems over a Wide Length-scale from Nanometer and Micrometer Sizes at the Small-angle Neutron Diffractometer KWS-2
11:27

Studying Soft-matter and Biological Systems over a Wide Length-scale from Nanometer and Micrometer Sizes at the Small-angle Neutron Diffractometer KWS-2

Published on: December 8, 2016

12.9K

Area of Science:

  • Materials Science
  • Biotechnology
  • Computational Chemistry

Background:

  • Surfactant-like peptides self-assemble at the nanoscale due to their amphiphilic nature.
  • These peptides offer potential for non-covalent functionalization of nanoparticles and macromolecules.

Purpose of the Study:

  • To investigate the supramolecular interactions between ultrashort carbon nanotubes (USCNTs), graphene (GR), and A9K polypeptides.
  • To determine the thermodynamic favorability and binding characteristics of these nanoscale carbon-peptide complexes.

Main Methods:

  • Utilized multiple equilibrium molecular dynamics simulations to sample phase space.
  • Employed the potential of mean force (PMF) to quantify binding affinities.
  • Incorporated position restraints where applicable to refine simulations.

Main Results:

  • Thermodynamically favorable binding was observed between A9K polypeptides and both USCNTs and GR.
  • Encapsulation of A9K within a (10,10) USCNT was found to be particularly favorable.
  • Binding of A9K to graphene was stronger than to the outer sidewall of USCNTs, with surface curvature influencing interaction.

Conclusions:

  • Non-covalent functionalization of nanoscale carbons with peptides like A9K is a viable strategy.
  • These peptide-functionalized nanomaterials hold promise for applications in biomaterials, biosensors, biomedical devices, and drug delivery systems.