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Association between pentraxin 3 levels and aortic valve calcification
Kenji Norimatsu1, Shin-Ichiro Miura2, Yasunori Suematsu1
1Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Plasma pentraxin 3 (PTX3) levels, along with age, independently predict aortic valve calcification (AVC) in patients without aortic valve stenosis (AS). This combination improves AVC evaluation accuracy.
Area of Science:
- Cardiology
- Radiology
- Biomarkers
Background:
- Aortic valve calcification (AVC) is a precursor to aortic valve stenosis (AS).
- Coronary computed tomography angiography (CTA) is effective for early AVC detection.
- Plasma pentraxin 3 (PTX3) is a potential biomarker.
Purpose of the Study:
- Investigate AVC presence in patients undergoing CTA.
- Examine the association between plasma PTX3 levels and AVC.
- Evaluate PTX3 as a predictor of AVC, especially in patients without AS.
Main Methods:
- Retrospective analysis of 162 patients undergoing CTA with measurable plasma PTX3.
- Patients categorized into AVC and non-AVC groups.
- Logistic regression analysis to identify predictors of AVC.
Main Results:
- AVC was independently associated with PTX3, age, chronic kidney disease, and coronary artery calcification.
- In patients without AS, PTX3 and age were independent predictors of AVC.
- Adding PTX3 to age improved specificity and positive predictive value for AVC.
Conclusions:
- PTX3 is an independent predictor of AVC in patients without AS.
- The combination of age and PTX3 offers a potentially superior approach for AVC evaluation.
- This finding may enhance early detection and management of aortic valve disease.
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