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Emergence of resistance in community-acquired enteric fever

Upma Narain1, Ritu Gupta

  • 1Tejas Micro diagnostic; and *Neonatal and Pediatric Unit, Priti Medical Research and Charitable Trust; Allahabad, India. docritugupta@gmail.com.

Indian Pediatrics
|September 22, 2015
PubMed

Insights

Antibiotic resistance in pediatric typhoid fever is common. Over 40% of patients showed resistance to ciprofloxacin and amoxicillin-clavulanic acid, highlighting the need for updated treatment guidelines.

Area of Science:

  • Infectious Diseases
  • Pediatric Medicine
  • Clinical Microbiology

Background:

  • Typhoid fever remains a significant public health concern in pediatric populations globally.
  • Emerging antibiotic resistance poses a challenge to effective treatment strategies for typhoid fever.

Purpose of the Study:

  • To analyze the antibiotic sensitivity patterns of pediatric patients with blood culture-proven typhoid fever.
  • To determine the prevalence of resistance to commonly prescribed oral antibiotics.

Main Methods:

  • Retrospective analysis of 225 pediatric patients.
  • Utilized Vitek-2 Systems for antibiogram generation.
  • Evaluated sensitivity to ciprofloxacin, amoxicillin-clavulanic acid, and cotrimoxazole.

Main Results:

  • High rates of resistance observed against commonly used oral antibiotics.
  • Resistance to ciprofloxacin was 41.4%.
  • Resistance to amoxicillin-clavulanic acid was 44.1%, and to cotrimoxazole was 32.7%.

Conclusions:

  • Commonly used oral antibiotics show significant resistance in pediatric typhoid fever cases.
  • Findings underscore the urgent need for reassessment of empirical antibiotic therapy guidelines for pediatric typhoid fever.

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