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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Spontaneous functional network dynamics and associated structural substrates in the human brain.

Xuhong Liao1, Lin Yuan2, Tengda Zhao2

  • 1State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University Beijing, China ; Center for Cognition and Brain Disorders, Hangzhou Normal University Hangzhou, China.

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Human brain networks are dynamic and efficient, with functional connectivity fluctuating over time. These spontaneous brain dynamics are linked to the brain's structural connections, revealing flexible coordination.

Keywords:
connectomicsfunctional dynamicsgraph theoryhubsliding windowsmall-world

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Area of Science:

  • Neuroscience
  • Network Science
  • Brain Imaging

Background:

  • Resting-state functional MRI (R-fMRI) reveals complex topology in human brain networks.
  • Limited understanding exists regarding dynamic functional connectivity (D-FC) during rest.
  • The influence of structural connectivity on spontaneous brain dynamics remains largely unexplored.

Purpose of the Study:

  • To investigate the dynamic characteristics of human whole-brain functional networks during rest.
  • To explore the relationship between dynamic functional connectivity and underlying structural connectivity.
  • To characterize the temporal and topological properties of spontaneous brain activity.

Main Methods:

  • Utilized sub-second multiband R-fMRI data for high temporal resolution.
  • Applied graph-theoretical approaches to analyze network topology.
  • Integrated diffusion imaging data to examine structural substrates.

Main Results:

  • Whole-brain D-FC patterns exhibited spontaneous temporal fluctuations.
  • Dynamic functional networks maintained small-world and assortative properties over time.
  • Persistent functional hubs showed high connectivity but variable degree centrality.
  • Temporal characteristics of D-FC were significantly associated with structural connectivity.

Conclusions:

  • Human brain networks demonstrate economical, efficient, and flexible dynamic functional coordination during rest.
  • Spontaneous brain dynamics are constrained by underlying structural connectivity.
  • This study enhances the understanding of human brain network dynamics and its structural basis.