Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aminoglycoside antibiotics moderately impair granulocyte function.

M M Seklecki, R Quintiliani, E G Maderazo

    Antimicrobial Agents and Chemotherapy
    |March 1, 1978
    PubMed
    Summary

    Five aminoglycoside antibiotics modestly increased granulocyte adherence and decreased migration in vitro. These drugs did not affect phagocytosis or nitroblue tetrazolium reduction in the study.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Antibiotic prophylaxis in eyes with filtration blebs: survey of glaucoma specialists, microbiological study, and recommendations.

    Journal of glaucoma·2009
    Same author

    Infusion phlebitis: relative incidence associated with cefuroxime administered by intermittent and continuous infusion.

    Clinical drug investigation·2008
    Same author

    Clinical management of respiratory tract infections in the community: experience with telithromycin.

    Infection·2002
    Same author

    Antibacterials for the prophylaxis and treatment of bacterial endocarditis in children.

    Paediatric drugs·2001
    Same author

    Moxifloxacin does increase the corrected QT interval.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
    Same author

    Guidelines for treatment of community-acquired pneumonia.

    Connecticut medicine·2001

    Area of Science:

    • Immunology
    • Pharmacology
    • Microbiology

    Background:

    • Aminoglycoside antibiotics are crucial for treating bacterial infections.
    • Understanding their impact on host immune cells, like granulocytes, is important for assessing treatment efficacy and potential side effects.

    Purpose of the Study:

    • To investigate the in vitro effects of five common aminoglycoside antibiotics on key granulocyte functions.

    Main Methods:

    • Utilized in vitro assays to assess granulocyte adherence, migration, phagocytosis, and nitroblue tetrazolium reduction.
    • Tested five aminoglycoside antibiotics: amikacin, kanamycin, gentamicin, tobramycin, and netilmicin.

    Main Results:

    • Aminoglycoside antibiotics demonstrated modest increases in granulocyte adherence.
    • A decrease in granulocyte migration was observed with these antibiotics.
    • No significant changes were found in granulocyte phagocytosis or nitroblue tetrazolium reduction.

    Conclusions:

    • Aminoglycoside antibiotics exert specific, modest modulatory effects on granulocyte adherence and migration in vitro.
    • These findings suggest that while aminoglycosides may influence neutrophil mobility, their impact on key bactericidal functions like phagocytosis and oxidative burst is minimal.

    Related Experiment Videos