Related Experiment Video

Updated: Apr 3, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

19.2K

Clinical Implications of Antiviral Resistance in Influenza

Timothy C M Li1, Martin C W Chan2, Nelson Lee3

  • 1Division of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, 9/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, China. liman1986@gmail.com.

Viruses
|September 22, 2015
PubMed

Insights

Influenza virus evolution drives antiviral resistance, particularly to neuraminidase inhibitors (NAIs). This review examines NAI resistance, its clinical impact, detection, and emerging treatments for influenza.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Influenza viruses constantly evolve, causing global epidemics and pandemics.
  • Antiviral resistance in influenza is a significant clinical and public health challenge.
  • Current influenza treatments include neuraminidase inhibitors (NAIs), M2 inhibitors, and favipiravir.

Purpose of the Study:

  • To review resistance issues associated with neuraminidase inhibitors (NAIs) for influenza treatment.
  • To discuss primary and secondary NAI resistance, including clinical implications and detection methods.
  • To explore novel therapeutic options for influenza currently in clinical trials.

Main Methods:

  • Literature review focusing on scientific publications and clinical data regarding NAI resistance.
  • Analysis of data on primary and secondary resistance mechanisms and prevalence.
  • Examination of diagnostic methods for detecting NAI resistance.
  • Review of ongoing clinical trials for new influenza therapeutics.

Main Results:

  • Data on primary and secondary resistance to NAIs will be presented.
  • Clinical implications of NAI resistance will be discussed.
  • Current detection methods and emerging therapeutic strategies will be outlined.

Conclusions:

  • Understanding and monitoring NAI resistance is crucial for effective influenza management.
  • Development of novel antiviral strategies is essential to combat evolving influenza strains.
  • Continued research into influenza virus evolution and drug resistance is vital for public health.
Keywords:
antiviral resistanceinfluenza virusesneuraminidase inhibitors

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