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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Skeletal Muscle Anatomy00:55

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Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
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Updated: Apr 3, 2026

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
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Tendinopathy: Update on Pathophysiology.

Alex Scott, Ludvig J Backman, Cathy Speed

    The Journal of Orthopaedic and Sports Physical Therapy
    |September 22, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Tendinopathy, a term for damaged tendons, is better understood through new insights into overuse injuries, biomechanics, and lifestyle factors affecting tendon pathology. These advancements offer improved clinical relevance for managing chronic tendon conditions.

    Keywords:
    collagenmedicationsoveruse injurytendinitis

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    Area of Science:

    • Orthopedics
    • Sports Medicine
    • Pathophysiology

    Background:

    • Tendinopathy is the accepted term for a range of tendon pathologies.
    • Recent decades have yielded significant advancements in understanding tendon disease.

    Purpose of the Study:

    • To review new insights into tendon pathophysiology.
    • To discuss the clinical relevance of these advancements for tendinopathy.

    Main Methods:

    • Literature review and synthesis of recent research on tendon pathophysiology.
    • Discussion of clinical implications of new findings.

    Main Results:

    • Enhanced characterization of overuse injury and its effects on chronically painful tendons.
    • Improved understanding of the pathomechanics of chronic tendon injuries.
    • Greater knowledge regarding the impact of lifestyle and drugs on tendon pathology.

    Conclusions:

    • New insights into tendon pathophysiology have significant clinical implications.
    • Understanding overuse, pathomechanics, and influencing factors can improve tendinopathy management.