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Updated: Apr 3, 2026

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Published on: December 9, 2017
Protein lysine acetylation in bacteria: Current state of the art
Tassadit Ouidir1,2,3, Takfarinas Kentache1,2,3, Julie Hardouin1,2,3
1CNRS, UMR 6270, Polymères, Biopolymères, Surfaces Laboratory, Mont-Saint-Aignan, France.
Abstract:
Post-translational modifications of proteins are key events in cellular metabolism and physiology regulation. Lysine acetylation is one of the best studied protein modifications in eukaryotes, but, until recently, ignored in bacteria. However, proteomic advances have highlighted the diversity of bacterial lysine-acetylated proteins. The current data support the implication of lysine acetylation in various metabolic pathways, adaptation and virulence. In this review, we present a broad overview of the current knowledge of lysine acetylation in bacteria. We emphasize particularly the significant contribution of proteomics in this field.
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