Related Experiment Video
Updated: Apr 3, 2026
Dissection of the Mouse Pancreas for Histological Analysis and Metabolic Profiling
Published on: August 19, 2017
Investigation of Morphological and Functional Changes in the Small Intestine With Pancreatic Disease
Yosuke Nakamura1, Akihiro Itoh, Hiroki Kawashima
1From the *Department of Endoscopy, Nagoya University Hospital; †Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine; and ‡Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan.
Objectives:
The aim of this study was to investigate the relationship between pancreas and small intestine evaluating the endoscopic and histopathologic findings of the proximal small intestine in pancreatic diseases.
Methods:
Fifty patients (18 patients with chronic pancreatitis, 17 patients with pancreatic cancer, 15 control subjects) underwent enteroscopy using a prototype enteroscope. The villous height of the jejunum on bioptic specimens was measured, and the mean values of the villi were compared among the 3 groups. Exocrine function was calculated by the pancreatic function diagnostic test, and the correlation between the recovery rate of p-aminobenzoic acid and the villous height was assessed. Finally, the distribution of the K cells secreting glucose-dependent insulinotropic polypeptide and the L cells secreting glucagon-like peptide 1 in the duodenum and jejunum was investigated using immunohistochemistry for glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1.
Results:
The mean villous height in chronic pancreatitis (328 ± 67 μm) was significantly lower than that in pancreatic cancer (413 ± 57 μm) and control subjects (461 ± 97 μm) (P = 0.004 and P < 0.0001, respectively). A positive correlation was found between the recovery rate of p-aminobenzoic acid and the villous height (r = 0.52, P = 0.0001). The presence of K and L cells was verified in the duodenum and the jejunum.
Conclusions:
Close relationship between pancreas and small intestine was demonstrated.
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