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Updated: Apr 3, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
[NON-CORONARY ATHEROSCLEROSIS PROGRESSION AFTER MYOCARDIAL INFARCTION IN PATIENTS OF DIFFERENT AGE GROUPS]
Insights
Following myocardial infarction (MI), younger patients (<60) experienced recurrent acute coronary syndromes (ACS), while older patients (>60) had cerebral vascular events. Atherosclerosis progression correlated with cardiovascular events in both age groups.
Area of Science:
- Cardiovascular Medicine
- Atherosclerosis Research
- Geriatric Cardiology
Context:
- Investigating non-coronary atherosclerosis progression post-myocardial infarction (MI).
- Analyzing age-related differences in cardiovascular event rates after ST-elevation MI (STEMI).
- Utilizing age 60 as a threshold for patient stratification.
Purpose:
- To compare the rate of atherosclerosis progression in patients younger and older than 60 years after MI.
- To determine the correlation between atherosclerosis intensity and subsequent cardiovascular events in different age groups.
- To identify distinct event patterns (ACS vs. cerebrovascular accidents) based on age post-MI.
Summary:
- A study of 168 STEMI patients revealed distinct outcomes one year post-MI based on age.
- Patients under 60 experienced recurrent ACS, whereas those 60 and older suffered cerebrovascular accidents.
- Atherosclerosis progression correlated with cardiovascular events in both groups; older patients showed increased cerebrovascular event risk.
Impact:
- Highlights age-specific risks and event types following MI.
- Underscores the link between atherosclerosis progression and both coronary and cerebrovascular events in older adults.
- Informs targeted preventive strategies for atherosclerosis management in post-MI patients across different age demographics.
Abstract:
The initial rate of non-coronary atherosclerosis progression in patients of different age groups before and after myocardial infarction (MI) was studied. 168 patients with ST elevation myocardial infarction (STEMI) were enrolled in the study; the age of 60 was a criterion for patients distribution into the study groups. It is established that one year after MI the patients younger than 60 years of age had recurrent acute coronary syndromes (ACS), and older patients had cerebral vascular accidents. Thus in both younger and older patients a correlation, between the presence and intensity of atherosclerosis progression and the rates of cardiovascular events was observed; however, in older patients atherosclerosis progression is associated not only with higher coronary but also cerebrovascular events rates.
Related Concept Videos
Atherosclerosis I: Introduction
Coronary Artery Disease I: Introduction
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Coronary Artery Disease II: Pathophysiology
Acute Coronary Syndrome III: Diagnostic Studies
Coronary Artery Disease III: Clinical Manifestations

