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[CHARACTERISTIC OF ALTERATIONS OF ARTERIES IN PATIENTS WITH ISCHEMIC HEART DISEASE AND CHRONIC HEPATITIS C]

N I Guliaev, V V Kuznetsov, D S Poltareĭko

    Advances in Gerontology = Uspekhi Gerontologii
    |September 23, 2015
    PubMed

    Insights

    Chronic viral hepatitis C (VHC) in older patients with ischemic heart disease is linked to more widespread atherosclerosis and generalized vascular changes, suggesting VHC contributes to atherogenesis through chronic immune inflammation.

    Area of Science:

    • Cardiology
    • Hepatology
    • Vascular Biology

    Background:

    • Ischemic heart disease (IHD) is a significant health concern in aging populations.
    • Chronic viral hepatitis C (VHC) is a prevalent condition that may influence cardiovascular health.
    • The interplay between VHC and atherosclerosis in IHD patients requires further investigation.

    Purpose of the Study:

    • To assess the degree and type of atherosclerosis in coronary and non-coronary vessels of elderly IHD patients with and without chronic VHC.
    • To evaluate the incidence of myocardial infarction in these patient groups.
    • To explore the potential role of chronic VHC in the process of atherogenesis.

    Main Methods:

    • Comparative analysis of atherosclerosis in IHD patients with and without chronic VHC.
    • Assessment of coronary and non-coronary vessel alterations.
    • Evaluation of myocardial infarction incidence and timing relative to IHD onset.

    Main Results:

    • IHD patients exhibit correlations between atherosclerosis and age/hypercholesterinemia.
    • Patients without chronic VHC had a higher risk of myocardial infarction, particularly in the early stages of IHD.
    • IHD patients with chronic VHC presented with more generalized and multifocal vascular alterations.

    Conclusions:

    • Chronic VHC is likely involved in atherogenesis, potentially by sustaining chronic immune inflammation in vascular endothelium.
    • Vascular alterations in IHD patients with VHC are more generalized and multifocal.
    • Understanding VHC's role in atherogenesis may inform cardiovascular risk management in affected individuals.

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