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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

355
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

323
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
323
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

325
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

342
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
342
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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[PROSPECTS OF INFORMATION INTERACTION OF MEDICAL AND PHARMACEUTICAL SPECIALISTS IN ASSISTING GERIATRIC PATIENTS].

A D Semenova, I A Kirshchina, A V Soloninina

    Advances in Gerontology = Uspekhi Gerontologii
    |September 23, 2015
    PubMed
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    Effective information exchange between medical and pharmaceutical professionals is crucial for elder healthcare. A conceptual model outlines necessary data and interaction protocols for improved health services.

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    Area of Science:

    • Gerontology
    • Health Informatics
    • Pharmaceutical Sciences

    Context:

    • Elderly healthcare requires seamless collaboration between medical and pharmacy sectors.
    • Current information exchange practices may be fragmented, impacting care quality for older adults.
    • The Perm region serves as a case study for implementing improved information sharing.

    Purpose:

    • To establish the necessity of robust information exchange for geriatric healthcare.
    • To define mandatory conditions for effective medical and pharmaceutical data sharing.
    • To propose a conceptual model for structured information interaction.

    Summary:

    • The study highlights the critical need for enhanced information exchange between doctors and pharmacists in geriatric care.
    • A conceptual model is presented, detailing essential information components, sender/receiver roles, and usage purposes.
    • The model's practical application is demonstrated within the context of the Perm region's healthcare system.

    Impact:

    • Facilitates better-coordinated and safer healthcare for the elderly population.
    • Improves the efficiency and effectiveness of health services delivery.
    • Provides a framework for optimizing inter-professional communication in pharmaceutical and medical fields.