[Study on solid dispersion of precipitated calcium carbonate-based oleanolic acid].

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Context:

• Oleanolic acid, a natural triterpenoid, exhibits various pharmacological properties but suffers from poor water solubility and bioavailability.
• Developing effective drug delivery systems is crucial for enhancing the therapeutic efficacy of poorly soluble compounds like oleanolic acid.

Purpose:

• To prepare and characterize oleanolic acid-precipitated calcium carbonate solid dispersion using a solvent evaporation method.
• To investigate the physicochemical properties, in vitro release, and stability of the developed solid dispersion.

Summary:

• Oleanolic acid-precipitated calcium carbonate solid dispersion was successfully prepared via solvent evaporation.
• Differential scanning calorimetry suggested oleanolic acid exists in an amorphous state within the dispersion.
• The solid dispersion (1:5 ratio) demonstrated a remarkable accumulated in vitro dissolution rate of up to 90% within 45 minutes.

Impact:

• The precipitated calcium carbonate carrier significantly improved the in vitro dissolution of oleanolic acid.
• Accelerated stability studies confirmed no change in content or dissolution after 6 months, indicating a stabilizing effect.
• The developed solid dispersion system holds significant potential for practical pharmaceutical applications due to enhanced dissolution and stability.