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A new predictor of mortality in hemodialysis patients; Tenascin-C

Sukru Ulusoy1, Gulsum Ozkan2, Ahmet Menteşe3

  • 1Department of Nephrology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.

Life Sciences
|September 23, 2015
PubMed

Insights

Tenascin C (TN-C) levels are elevated in hemodialysis patients and predict cardiac mortality. Higher TN-C levels are associated with increased cardiovascular and all-cause mortality risk in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarkers

Background:

  • Cardiovascular disease is a leading cause of death in hemodialysis patients.
  • Cardiovascular risk factors in hemodialysis patients are not fully understood.
  • Tenascin C (TN-C) is implicated in cardiac disease prognosis.

Purpose of the Study:

  • To measure Tenascin C (TN-C) levels in hemodialysis patients.
  • To assess the association between TN-C levels and cardiac mortality.
  • To identify TN-C as a potential biomarker for cardiac risk in hemodialysis.

Main Methods:

  • Multicenter prospective observational study.
  • Blood samples collected for TN-C and biochemical analysis.
  • Two-year follow-up for mortality and parameter association.

Main Results:

  • Hemodialysis patients showed higher TN-C levels than controls (p < 0.001).
  • TN-C, age, and systolic blood pressure independently predicted cardiac mortality.
  • Elevated TN-C correlated with increased all-cause and cardiac mortality (Log rank p < 0.001 and p < 0.05).

Conclusions:

  • Tenascin C (TN-C) levels are significantly higher in hemodialysis patients.
  • TN-C may serve as a predictor of cardiac mortality in this cohort.
  • Further research could establish TN-C as a valuable biomarker for cardiac risk assessment.
Abstract

Keywords:
Cardiac mortalityHemodialysisMortalityTenascin C

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