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Immobilizing water-soluble graphene quantum dots with gold nanoparticles for a low potential electrochemiluminescence
Yongqiang Dong1, Huan Wu, Pengxiang Shang
1Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, and Department of Chemistry, Fuzhou University, Fujian 350108, China. y.w.chi@fzu.edu.cn.
Abstract:
Hydrazide-modified graphene quantum dots (HM-GQDs) obtained by refluxing GQDs with hydrazine hydrate were hybridized with gold nanoparticles (AuNPs) through a redox reaction between HM-GQDs and AuCl4(-). The obtained nano-hybrids (HM-GQD-AuNPs) possess the unique electrochemiluminescence (ECL) properties of HM-GQDs and the easy self-assembly with some bio-molecules of AuNPs, which have great potential applications in bio-sensors. HM-GQD-AuNPs were modified on a glassy carbon electrode to develop a novel ECL immunosensor of carcinoembryonic antigen (CEA) as a model target analyte. Due to the increment of electron-transfer resistance after immunoreaction, the ECL intensity decreased as the concentration of CEA was increased. The linear response range was between 0.02 and 80 ng mL(-1), and the detection limit was 0.01 ng mL(-1).
