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Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function.
Kazumasa Matsumoto-Miyai1,2,3, Masaru Yoshizumi4, Masahito Kawatani4
1Department of Neurophysiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan. k.miyai@kki.ac.jp.
Advances in Therapy
|September 23, 2015
Summary
Serotonin (5-hydroxytryptamine) influences lower urinary tract function through various receptor subtypes. Targeting these 5-HT receptors offers potential new treatments for urinary tract symptoms.
Area of Science:
- Pharmacology
- Urology
- Neuroscience
Background:
- 5-hydroxytryptamine (5-HT; serotonin) plays significant physiological and pathological roles in the lower urinary tract.
- Numerous 5-HT receptor subtypes are expressed in peripheral and central organs involved in urinary tract function.
Purpose of the Study:
- To review the diverse roles of 5-HT receptor subtypes in the lower urinary tract.
- To explore the potential of 5-HT receptor subtypes as therapeutic targets for lower urinary tract symptoms.
Main Methods:
- Review of existing literature on 5-HT receptor expression and function in the lower urinary tract.
- Analysis of the physiological and pathological implications of different 5-HT receptor subtypes.
Main Results:
- Specific 5-HT receptor subtypes (5-HT1A, 5-HT2, 5-HT3, 5-HT7) act as postjunctional receptors on bladder smooth muscle, influencing detrusor contraction and relaxation.
- Multiple 5-HT receptor subtypes (5-HT1A, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, 5-HT7) function as prejunctional receptors, modulating neurotransmitter release and neurogenic contraction.
- Central 5-HT pathways involving 5-HT1A, 5-HT2A, and 5-HT7 receptors regulate bladder and urethral sphincter activity.
- 5-HT may also influence prostate function and cell proliferation.
Conclusions:
- 5-HT receptor subtypes exhibit complex roles in regulating lower urinary tract function, including bladder contraction, relaxation, and sensation.
- Targeting specific 5-HT receptor subtypes presents a promising avenue for developing novel therapeutics for various lower urinary tract symptoms.
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