Histological study of the occipital bone from patients with Chiari I malformation
R Shane Tubbs1,2, Annie Laurie Benzie3, Elias Rizk4
1Seattle Science Foundation, Seattle, WA, USA. shane.tubbs@childrensal.org.
Background:
This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition.
Methods:
Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis.
Results:
For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples.
Conclusions:
Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.
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