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Critical issues in cancer vaccine trial design
Guy T Clifton1, Holbrook E Kohrt2, George E Peoples3
1University of Texas MD Anderson Cancer Center, Department of Surgical Oncology, Houston, TX, USA.
Abstract:
As the clinical experience with cancer vaccines and cancer immunotherapy increases, there are important lessons that can be learned from the successes and failures of past trials. Many lessons affect the design and conduct of clinical trials themselves. Appropriate patient selection, clinical trial design, immunologic monitoring, and appropriate endpoints are all essential to the efficiency and success of bringing cancer vaccines from conception to clinical use.
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