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Development of a microwave-induced hyperthermia system with multiple applicators.

Y Onizuka

    The Kurume Medical Journal
    |January 1, 1989
    PubMed
    Summary

    A new microwave hyperthermia system uses helical coil applicators to treat superficial tumors up to 5 cm deep. This system, controlled by microcomputers and temperature feedback, has been used in 70 patients with various cancers.

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    Area of Science:

    • Medical Physics
    • Oncology
    • Biomedical Engineering

    Background:

    • Hyperthermia, the therapeutic use of heat, is an effective adjuvant to radiotherapy for various cancers.
    • Superficial tumors, particularly in curved anatomical regions, present challenges for uniform and effective heat delivery.
    • Previous hyperthermia systems lacked the precision and adaptability required for complex body contours.

    Purpose of the Study:

    • To describe a novel microwave hyperthermia system designed for clinical application.
    • To evaluate the system's capability in delivering localized hyperthermia to superficial tumors.
    • To assess the system's performance in terms of temperature distribution and energy deposition.

    Main Methods:

    • Development of a hyperthermia system utilizing five helical coil applicators operating at 2450 MHz.
    • Application of superimposed microwave beams for targeted heating of superficial tumors (approx. 5 cm depth) in challenging anatomical areas.
    • Microcomputer control of microwave generators based on real-time temperature measurements from inserted thermocouple probes.
    • Evaluation of specific absorption rate (SAR) in agar gel phantoms and temperature-depth profiles in patients.

    Main Results:

    • The system successfully induced hyperthermia in superficial tumors, including those in extremities, breasts, head, and neck.
    • Temperature-depth relationships were measured in four patients, demonstrating controlled heating with 2-4 applicators (250-600 Watt).
    • The system's ability to deliver localized energy deposition was confirmed through phantom studies.

    Conclusions:

    • The described microwave hyperthermia system is clinically viable for treating superficial tumors.
    • The system offers precise temperature control and effective heat delivery in anatomically complex regions.
    • Combined with radiotherapy, this hyperthermia system has been successfully applied to 70 patients with various malignancies.

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