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Spinal epidural abscess following treatment with rituximab
J D Avila1,2, S Živković2
1Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.
Objective:
To describe spinal epidural abscess after treatment with rituximab.
Methods:
Report of a new case of cervical epidural spinal abscess after treatment with rituximab and review of the literature.
Results:
Biologic agents are associated with an increased risk of serious infections, there are only few reports of spinal epidural abscesses following immunomodulatory treatment with biologic agents, including only one other case of an epidural abscess after the use of rituximab. The risk may be greater with the use of other immunosuppressive medications, or with combined immunotherapy.
Conclusion:
Spinal epidural abscess is a rare complication with potential severe morbidity, and continued vigilance is needed as timely intervention may prevent severe morbidity and potentially fatal outcome.
