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Related Experiment Video

Updated: Apr 3, 2026

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Integrating plasmonic diagnostics and microfluidics.

Lifang Niu1, Nan Zhang1, Hong Liu1

  • 1Institute of Materials Research and Engineering , 3 Research Link, Singapore 117602, Singapore.

Biomicrofluidics
|September 23, 2015
PubMed
Summary
This summary is machine-generated.

Plasmonics integrated with microfluidics offers sensitive biosensing for point-of-care diagnostics. This approach combines surface plasmon resonance (SPR) and localized SPR (LSPR) for detecting various biomolecular analytes.

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Area of Science:

  • Optics and Photonics
  • Biotechnology
  • Nanotechnology

Background:

  • Plasmonics, encompassing surface plasmon resonance (SPR) and localized SPR (LSPR), utilizes electromagnetic modes on metal/dielectric interfaces or nanostructures.
  • Integration of plasmonic optical transducers with microfluidic devices offers advantages like small footprint, low cost, and array format suitability for biosensing.

Purpose of the Study:

  • To demonstrate the combination of plasmonics and integrated microfluidics for diverse biomolecular analyte detection.
  • To showcase various plasmonic generation mechanisms and detection schemes tailored for specific analytes.

Main Methods:

  • Development of plasmonic chips and microfluidic channels.
  • Surface bio-functionalization strategies.
  • Utilizing different plasmonic detection methods including surface plasmon fluorescence spectroscopy, grating-coupled SPR, and LSPR-based detection (wavelength shift, quantum dot excitation).

Main Results:

  • A DNA sensor array using a gold film and surface plasmon fluorescence spectroscopy.
  • Grating-coupled SPR for poly(ethylene glycol) thiol interaction detection.
  • Gold nanohole-based LSPR for biotin-streptavidin detection.
  • Gold nanoholes/nanopillars for prostate-specific antigen detection using quantum dot labels.

Conclusions:

  • Plasmonic integrated microfluidics is a powerful tool for studying biomolecular interactions and molecular recognition.
  • This technology shows significant promise for on-site and point-of-care diagnostic applications.