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Updated: Apr 3, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Tuberculosis-diabetes mellitus bidirectional screening at a tertiary care centre, South India
B C Prakash1, K S Ravish2, B Prabhakar1
1Bowring and Lady Curzon Hospital, Bangalore, India ; Bangalore Medical College & Research Institute, Bangalore, India.
Insights
Bidirectional screening for tuberculosis (TB) and diabetes mellitus (DM) is feasible and effective for identifying diabetes in TB patients. Further research is needed to improve TB detection in diabetes patients.
Area of Science:
- Public Health
- Infectious Diseases
- Endocrinology
Background:
- Diabetes mellitus (DM) and tuberculosis (TB) are significant global health challenges.
- Co-infection with DM and TB complicates diagnosis and treatment.
- Effective screening strategies are crucial for managing these co-existing conditions.
Purpose of the Study:
- To evaluate the feasibility and outcomes of a bidirectional screening program for TB and DM.
- To determine the prevalence of DM among TB patients and vice versa.
- To assess the effectiveness of integrated care pathways.
Main Methods:
- A descriptive study was conducted at a tertiary care center in Bangalore, India.
- TB patients were screened for DM, and DM patients were screened for TB.
- Diagnostic criteria included fasting blood glucose levels for DM and clinical assessment for TB.
Main Results:
- Of 510 TB patients, 6.3% had pre-existing DM. Screening identified an additional 2.9% with pre-diabetes and 2.9% newly diagnosed with DM.
- Higher DM prevalence was observed in TB patients aged ≥40, those with pulmonary TB, and smokers.
- Screening of 1670 DM patients identified 45 with active TB, and further screening of those with TB symptoms yielded 2 new TB cases.
Conclusions:
- Bidirectional screening for TB and DM is feasible and highly effective for detecting DM in TB patients.
- The yield for detecting TB among DM patients was low, suggesting a need for improved diagnostic tools.
- Integrated screening programs can enhance patient management for co-existing TB and DM.
Setting:
Tuberculosis (TB) and diabetes mellitus (DM) clinics at Bowring and Lady Curzon Hospital, a tertiary care centre in Bangalore, India.
Obejctive:
To assess the feasibility and results of TB-DM bidirectional screening.
Methods:
A descriptive study conducted from 1 March to 30 September 2012, in which all TB patients were assessed for DM and vice versa. Fasting blood glucose values of ≥126 mg/dl and 110-125 mg/dl were considered as DM and pre-diabetes, respectively.
Results:
Of 510 TB patients, 32 (6.3%) had been previously diagnosed with DM. Screening among the remaining 478 patients yielded 15 (2.9%) with pre-diabetes and 15 (2.9%) newly diagnosed cases of DM. A higher prevalence of DM was found among patients aged ≥40 years, patients with pulmonary TB and smokers. Of the 47 TB-DM patients, 45 were enrolled in DM care. Of 1670 DM patients followed up in DM clinics, 45 already had TB. Among the remaining 1625 patients screened, 152 (9%) had symptoms suggestive of TB; two of these were found to have the disease.
Conclusion:
Bidirectional screening for DM and TB is feasible and produces a high yield for DM among TB patients. The yield of TB among DM patients was low and needs future research using new, improved TB diagnostic tools.
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