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Updated: Apr 3, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three new 1α-alkyldaphnane-type diterpenoids from the flower buds of Wikstroemia chamaedaphne
Jieru Guo1, Jun Tian2, Guangmin Yao3
1Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Abstract:
Three new 1α-alkyldaphnane type diterpenoids, wikstroelides R-T (1-3), together with three known analogs, genkwadane C (4), pimelea factors S6 (5) and S7 (6), two known 1α-alkyldaphnane ketal-lactone type diterpenoids, pimelotides A (7) and C (8), and a known daphnane type diterpenoid, simplexin (9), were isolated from the flower buds of Wikstroemia chamaedaphne. Their structures were elucidated by a combination of spectroscopic analyses including HRESIMS and NMR. Compounds 1-9 were evaluated for their cytotoxic activities in vitro, and most of them exhibited moderate cytotoxic activities with IC50 values ranging from 8.7-22.0 μM.
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