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[Substance dependence and genetic polymorphisms].

Daisuke Nishizawa, Kazutaka Ikeda

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |September 24, 2015
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    Summary
    This summary is machine-generated.

    Individual vulnerability to substance dependence is influenced by genetic and environmental factors. This review explores the associations between genetic polymorphisms, like single nucleotide polymorphisms (SNPs), and substance dependence risk.

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    Area of Science:

    • Genetics
    • Neuroscience
    • Pharmacology

    Context:

    • Individual differences in substance dependence vulnerability are well-established.
    • Both genetic and environmental factors contribute to varying susceptibility.
    • Numerous molecules and genetic variations are implicated in substance dependence.

    Purpose:

    • To review current evidence on the association between genetic polymorphisms and substance dependence vulnerability.
    • To highlight advancements in genotyping technologies, particularly single nucleotide polymorphisms (SNPs).

    Summary:

    • Genetic factors play a significant role in an individual's susceptibility to substance dependence.
    • Advances in genotyping technologies have facilitated the identification of genetic associations.
    • Single nucleotide polymorphisms (SNPs) are frequently studied in relation to substance dependence.

    Impact:

    • Provides a comprehensive overview of genetic associations with substance dependence.
    • Informs future research directions in personalized medicine for addiction treatment.
    • Enhances understanding of the genetic underpinnings of substance use disorders.