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Attention-Deficit/Hyperactivity Disorder Medication Treatment Impact on Response to Growth Hormone Therapy: Results

Susan R Rose1, Grafton Reeves2, Robert Gut3

  • 1Departments of Pediatric Endocrinology and Metabolism, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

The Journal of Pediatrics
|September 24, 2015
PubMed

Insights

Attention-deficit/hyperactivity disorder (ADHD) stimulant medication did not alter linear growth in children receiving growth hormone (GH) treatment. However, ADHD medication was associated with a greater BMI increase in patients with GH deficiency.

Area of Science:

  • Pediatric Endocrinology
  • Neurodevelopmental Disorders

Background:

  • Growth hormone (GH) therapy is used for short stature in children.
  • Attention-deficit/hyperactivity disorder (ADHD) is common in children and often treated with stimulant medication.
  • The potential impact of ADHD stimulant medication on GH treatment outcomes requires investigation.

Purpose of the Study:

  • To determine if ADHD stimulant medication influences linear growth in children undergoing GH treatment.
  • To analyze the effect of concomitant ADHD medication on height standard deviation score (HSDS) and body mass index standard deviation score (BMI SDS) changes.

Main Methods:

  • Analysis of data from the American Norditropin Studies: Web-Enabled Research Program.
  • Comparison of linear growth in GH-treated children with and without ADHD stimulant medication.
  • Use of linear mixed models to assess changes in HSDS and BMI SDS over 4 years.
  • Matching of ADHD groups based on baseline characteristics to control for confounding factors.

Main Results:

  • Linear growth (HSDS change) was similar between children receiving and not receiving ADHD stimulant medication when matched for baseline measurements.
  • A slightly lower adjusted change in HSDS was observed in the ADHD medication group at years 1-4 before matching.
  • A greater adjusted change in BMI SDS was observed in patients receiving ADHD stimulant medication, particularly those with GH deficiency.

Conclusions:

  • ADHD stimulant medication does not appear to affect the linear growth response to GH treatment in children when baseline characteristics are considered.
  • The increased BMI SDS in children with GH deficiency on ADHD medication warrants further research to understand the underlying mechanisms.
Abstract

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