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Sentinel lymph node biopsy in thick malignant melanoma: A 16-year single unit experience
Robert E Hunger1, Aude Michel2, S Morteza Seyed Jafari1
1University Clinic for Dermatology.
Background:
The role of sentinel lymph node biopsy (SLNB) and its benefits in patients with thick melanoma is still controversial.
Objectives:
We evaluated the clinical effect of SLNB in patients with thick melanoma.
Methods:
We performed a retrospective cohort review (1996-2012) of thick melanomas. Collected data included the patient and tumour characteristics. Locoregional recurrence, distant metastases, disease free and overall survival were compared between the patients with positive and negative SLNB.
Results:
126 thick melanomas with a mean age of 64.09 years were included in the study. Positive SLNB were found in 47 (37.3%) patients. Significantly more locoregional recurrence (P = 0.002) and distant metastases (P = 0.030) were detected in the patients with positive SLNB. Furthermore, the patients with negative SLNB showed significantly better disease free survival (P = 0.021).
Conclusions:
Positive SLNB might be prognostic factor in thick melanoma and aggravates the outcome of thick melanomas.
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