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Probable interaction between acenocoumarol and levofloxacin: a case series
I Palacios-Zabalza1, M Bustos-Martínez1, J Peral-Aguirregoitia1
1Department of Pharmacy, Galdakao- Usansolo Hospital, Galdakao, Bizkaia, Spain.
What Is Known And Objective:
To report five cases with a probable interaction between acenocoumarol and levofloxacin.
Case Description:
In five patients on long-term acenocoumarol treatment who had had stable international normalized ratios for at least 6 months, sudden erratic changes in the values of these ratios were observed after 1.5-8 days of concomitant levofloxacin treatment with no other apparent cause.
What Is New And Conclusions:
Closer monitoring should be considered in patients with concomitant use of acenocoumarol and levofloxacin, especially elderly patients and those with renal dysfunction who seemed to suffer the interaction more severely.
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