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Related Concept Videos

Pancreas01:19

Pancreas

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
3.2K

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Related Experiment Video

Updated: Apr 3, 2026

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

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Human pancreas development.

Rachel E Jennings1, Andrew A Berry2, James P Strutt2

  • 1Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester M13 9WU, UK rachel.jennings@manchester.ac.uk neil.hanley@manchester.ac.uk.

Development (Cambridge, England)
|September 24, 2015
PubMed
Summary
This summary is machine-generated.

This review synthesizes human embryonic and fetal pancreas development research. Findings inform the creation of insulin-producing beta cells and understanding diabetes, particularly neonatal forms.

Keywords:
DevelopmentEmbryoEndodermFetalForegutGestationHumanLiverPancreasStem cellsTranscription factorβ-cells

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Area of Science:

  • Developmental Biology
  • Endocrinology
  • Stem Cell Biology

Background:

  • Extensive research exists on mammalian and vertebrate pancreas development.
  • Human pancreatic development has been less comprehensively reviewed.
  • This study focuses on data from human embryonic and fetal tissues.

Purpose of the Study:

  • To provide an overview of human pancreatic development based on direct tissue studies.
  • To connect human pancreas development knowledge to stem cell-based beta cell manufacturing.
  • To explore the relevance to diabetes, including permanent neonatal diabetes.

Main Methods:

  • Literature review of studies using human embryonic and fetal pancreatic tissue.
  • Synthesis of existing research findings.
  • Discussion of implications for regenerative medicine and disease etiology.

Main Results:

  • Detailed overview of key stages and processes in human pancreas development.
  • Identification of critical developmental pathways and cellular behaviors.
  • Established links between developmental processes and disease mechanisms.

Conclusions:

  • Human pancreas development research is crucial for advancing regenerative medicine.
  • Understanding human development aids in elucidating causes of neonatal diabetes.
  • This review consolidates knowledge to guide future research and therapeutic strategies.