Related Experiment Video
Updated: Apr 3, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
[Fragility assessment in primary care: which tools for predicting what?]
Flavie Gleize1, Jadwiga Zmudka2, Yoann Lefresne3
1Service de médecine gériatrique, Centre hospitalier Saint-Quentin, France.
In primary care, 10.9% of older adults were frail, with 56.4% pre-frail. Early screening using grip strength and Instrumental Activities of Daily Living (IADL) can help manage frailty progression.
Area of Science:
- Geriatrics
- Primary Care Medicine
- Public Health
Background:
- Frailty is a significant geriatric syndrome linked to adverse outcomes like falls, disability, hospitalization, and mortality.
- Assessing frailty prevalence and progression in primary care is crucial for timely interventions.
- The Fried frailty criteria provide a standardized definition but require evaluation for primary care implementation.
Purpose of the Study:
- To determine the prevalence of frailty using Fried's criteria in a primary care setting.
- To examine the evolution of frailty status over one year in patients over 75 years old.
- To identify potential simple screening tools for frailty in general practice.
Main Methods:
- A descriptive prospective study involving patients aged 75 and older consulting three general practitioners.
- Frailty assessment based on Fried's criteria: weight loss, weakness (grip strength), exhaustion, low physical activity, and slow walking speed.
- Patients were evaluated at baseline and again at one year.
Main Results:
- Of 55 re-evaluated patients, 10.9% were classified as frail, 56.4% as pre-frail, and 32.7% as robust.
- Patients transitioning from robust to frail showed significantly lower Instrumental Activities of Daily Living (IADL) scores and grip strength compared to those remaining robust.
- The Fried tool proved challenging to implement in the primary care setting.
Conclusions:
- Frailty is prevalent in the primary care population, with a substantial proportion of older adults being pre-frail.
- Grip strength and IADL scores show promise as simple screening tools for early frailty detection in general practice.
- Implementing early screening and intervention can potentially delay the progression of frailty and its associated negative outcomes.
More Related Videos
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024