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Updated: Apr 3, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Light pigmentation phenotype is correlated with increased substantia nigra echogenicity
Jost-Julian Rumpf1, Maria Schirmer1, Christopher Fricke1
1Department of Neurology, University of Leipzig, Leipzig, Germany.
Objective:
This study was undertaken to address the question of whether pigmentation may be mechanistically linked with Parkinson's disease.
Methods:
In a cross-sectional, observational study, 116 healthy subjects received transcranial sonography of the substantia nigra. Pigmentation phenotype was assessed using the Fitzpatrick skin phototype classification, and five additional phenotypic pigmentation traits as well as a photographic method (Melanin index) in a subgroup of 46 subjects.
Results:
Lighter skin phototype was associated with larger echogenic substantia nigra area and increased prevalence of abnormally enlarged echogenic substantia nigra area. The strongest association of substantia nigra echogenicity and phenotypic pigmentation traits was found for hair color and facial tanning.
Interpretation:
Findings suggest an increasing prevalence of structural abnormality of substantia nigra with decreasing darkness of skin and thus may provide additional evidence in favor of a pathogenic link of pigmentation and Parkinson's disease.
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