Related Experiment Videos
Potentiation of cyclophosphamide-induced enhancement of experimental metastasis by splenectomy
1Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Wroclaw.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1989
Abstract:
Role of spleen in CY-induced enhancement of experimental lung metastases of Lewis Lung Carcinoma LL2 cells was studied. Reconstitution with spleen cells abolished the enhancing effect of CY. Conversely, removal of spleen in CY treated mice caused about two-fold increase in the number of metastases. In addition in splenectomized mice, the effect of CY was augmented.