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The effect of Corynebacterium parvum in influenza infected mice
J Białek1, A Denys, M Kowalska
1Department of Medical Microbiology, Military Medical Academy, Lódź.
Abstract:
This paper is the continuation of earlier studies on the effect of the killed suspension of Corynebacterium parvum in influenza virus infected mice. Our investigation showed the normalized effect of these drugs on disturbed function of cell mediated immunity during experimental influenza infection especially in phagocytic and bactericidal activity of granulocytes. The present experiments concern the explanation of these infection mechanisms. Intraperitoneal injection of Corynebacterium parvum stimulated spleen index. Foot pad test is higher than in comparatively treated BCG group. The pathomorphological analysis of the spleen, thymus and peritoneal lymph nodes points out to the multiplication of multiple lymph nodes sinus cells. Generally, C. parvum possessed protective effect in experimental influenza infection. We tested the following parameters: phagocytic and bactericidal activity of granulocytes, liberation of leukocytes migration inhibition factor (LIF).
Insights
Corynebacterium parvum administration normalized immune function in mice with experimental influenza. This immunotherapy demonstrated a protective effect against influenza infection by enhancing granulocyte activity and immune cell proliferation.
Area of Science:
- Immunology
- Microbiology
- Virology
Background:
- Influenza virus infections can disrupt cell-mediated immunity.
- Previous studies explored Corynebacterium parvum's effects on immune responses.
Purpose of the Study:
- To further investigate the immunomodulatory mechanisms of Corynebacterium parvum in experimental influenza.
- To assess the protective effects of Corynebacterium parvum against influenza infection in mice.
Main Methods:
- Mice were infected with influenza virus and treated with killed Corynebacterium parvum suspension.
- Evaluated phagocytic and bactericidal activity of granulocytes.
- Measured leukocyte migration inhibition factor (LIF) and performed pathomorphological analysis of immune organs.
Main Results:
- Corynebacterium parvum treatment normalized cell-mediated immunity, including granulocyte function.
- Intraperitoneal injection of Corynebacterium parvum increased spleen index and footpad test responses compared to BCG.
- Pathomorphological analysis revealed lymph node sinus cell multiplication.
Conclusions:
- Corynebacterium parvum exhibits a protective effect against experimental influenza infection in mice.
- The immunotherapy enhances key immune parameters, suggesting its potential therapeutic value.