Related Experiment Video
Updated: Apr 3, 2026

09:45
Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
7.5K
Congenital syphilis: The continuing scourge
Prachi G Agrawal1, Rajesh Joshi2, Vidya D Kharkar1
1Department of Skin and VD, Gordhandas Sunderdas Medical College and King Edward Memorial Hospital (GSMC and KEMH), Mumbai, Maharashtra, India.
Indian Journal of Sexually Transmitted Diseases and AIDS
|September 24, 2015
Summary
Congenital syphilis, a severe infection from Treponema pallidum, poses diagnostic challenges in newborns. Early screening of pregnant women is crucial to prevent serious infant outcomes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Congenital syphilis results from in utero or intrapartum transmission of Treponema pallidum.
- Despite declining incidence, it causes significant perinatal morbidity and mortality.
- Early diagnosis is challenging due to asymptomatic infants and nonspecific symptoms in others.
Observation:
- A case of a 2-month-old infant with early congenital syphilis is presented.
- The infant exhibited joint swellings and Parrot's pseudoparalysis.
- These specific signs are relatively rare in contemporary congenital syphilis cases.
Findings:
- Congenital syphilis can present with subtle or severe symptoms, including joint issues and paralysis.
- The disease highlights diagnostic difficulties in neonates and infants.
- Timely identification and treatment are critical for preventing long-term complications.
Implications:
- Emphasizes the need for universal syphilis screening in pregnant women during the first and late trimesters.
- Reinforces adherence to CDC recommendations for prenatal care.
- Highlights the importance of recognizing rare presentations for prompt diagnosis and management of congenital syphilis.
Related Concept Videos
Sexually Transmitted Infections
1.6K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.6K
Cytomegalovirus Disease
27
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
27
Immunodeficiency Diseases
3.1K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
3.1K
Sex-linked Disorders
111.3K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
111.3K
Diphtheria
72
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
72
Development of Immunocompetence
1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K

