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Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents

Dong-Jin Hwang1, Jin Wang1, Wei Li1

  • 1Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center , Memphis, Tennessee 38163, United States.

ACS Medicinal Chemistry Letters
|September 24, 2015
PubMed

Keywords:
Colchicine-binding siteantiproliferative activityliver microsomal stabilitymelanomamultiple drug resistanceprostate cancerstructure−activity relationship (SAR)tubulin polymerization inhibitor

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