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Estimating the Amount of Hemoglobin in the Neuroretinal Rim Using Color Images and OCT.

Erica Medina-Mesa1, Marta Gonzalez-Hernandez1, Jose Sigut2

  • 1a Hospital Universitario de Canarias, University of La Laguna , Santa Cruz de Tenerife , Spain and.

Current Eye Research
|September 24, 2015
PubMed
Summary

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Hemoglobin (Hb) in the optic nerve head (ONH) is significantly lower in glaucoma patients. Reduced Hb in ONH rim sectors correlates with visual field loss, indicating potential perfusion issues in glaucoma.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Optic nerve head (ONH) structure and function are critical in glaucoma diagnosis.
  • Assessing ONH perfusion may offer new diagnostic insights.

Purpose of the Study:

  • To quantify hemoglobin (Hb) in the optic nerve head (ONH).
  • To investigate the relationship between ONH Hb levels and glaucoma.
  • To evaluate Hb as a diagnostic indicator for glaucoma.

Main Methods:

  • Utilized Cirrus-OCT and Visucam for ONH imaging in 100 healthy and 121 glaucomatous eyes.
  • Employed the Laguna ONhE program to calculate Hb in ONH cup and rim sectors.
  • Performed Receiver Operating Characteristic (ROC) analysis and correlation studies.
Keywords:
Glaucomahemoglobinoptic nerve headperfusionperimetryvisual field

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Main Results:

  • Significantly lower Hb levels were observed in all ONH rim sectors of glaucoma patients compared to controls.
  • Hb levels in superior and inferior rim sectors showed a stronger correlation with Mean Deviation (MD) than rim area or nerve fiber layer thickness.
  • OCT rim area, vertical cup/disc ratio (C/D), and Glaucoma Discriminant Function (GDF) were identified as key diagnostic indicators.

Conclusions:

  • ONH Hb levels are closely linked to visual field sensitivity in glaucoma.
  • Reduced Hb in the ONH rim suggests insufficient perfusion in many glaucoma cases.
  • Hb quantification may serve as a valuable biomarker in glaucoma assessment.