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Histone Modifications and Asthma. The Interface of the Epigenetic and Genetic Landscapes

Courtney D A Kidd1,2, Philip J Thompson1,2,3, Lucy Barrett1,2

  • 11 Institute for Respiratory Health, Perth, Western Australia, Australia.

American Journal of Respiratory Cell and Molecular Biology
|September 24, 2015
PubMed

Keywords:
asthmaasthma severityepigeneticshistone codehistone modifications

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Histone Modification02:32

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Acetylation
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Critical processes in asthma pathophysiology include:
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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