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Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia
R Pirker1, L J Goldstein, H Ludwig
1First Medical Clinic, University of Vienna Medical School, Austria.
Cancer Communications
|January 1, 1989
Abstract:
Three of four patients with chronic myelogenous leukemia in blast crisis were found to express the multidrug resistance (MDR1) gene in their blast cells. Expression of the MDR1 gene may contribute to the poor response of these patients to chemotherapy.