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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Predisposing factors endorsing Candida infections.

Shweta Singh1, Zeeshan Fatima1, Saif Hameed1

  • 1Amity Institute of Biotechnology, Amity University Haryana, Gurgaon (Manesar), India.

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Candida albicans is a common fungal pathogen causing infections from superficial to systemic. Understanding predisposing factors is crucial for managing rising candidal infections, especially in hospitals.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Candida albicans is an opportunistic human fungal pathogen.
  • It causes infections ranging from superficial and mucosal to systemic candidiasis.
  • Candidal infections are a leading cause of death in nosocomial infections and are increasing globally.

Purpose of the Study:

  • To review and consolidate the understanding of predisposing factors for Candida albicans infections.
  • To highlight the increasing incidence and clinical significance of candidiasis.
  • To emphasize the need for a comprehensive platform discussing these factors.

Main Methods:

  • This is a review article.
  • It synthesizes information on immunologic and non-immunologic predisposing factors.
  • The article discusses various factors contributing to host susceptibility.

Main Results:

  • Candidal infections are rising due to factors like poor clinical management, antibiotic overuse, drug resistance, immunosuppression, and host-pathogen interactions.
  • Both immunologic and non-immunologic factors contribute to susceptibility.
  • A unified understanding of these factors is needed.

Conclusions:

  • Predisposing factors significantly influence the development of candidal infections.
  • Further research and clinical attention are required to address the increasing burden of candidiasis.
  • A comprehensive approach to understanding predisposing factors is essential for effective management.