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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Apr 3, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Infarct-Associated Bone Sarcomas: Multimodality Imaging Findings.

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  • 11 Department of Radiology, University of Chicago, 5841 S Maryland Ave, MC 2026, Chicago, IL 60637.

AJR. American Journal of Roentgenology
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Summary
This summary is machine-generated.

Infarct-associated bone sarcomas are rare but can be challenging to diagnose. Radiologists should be vigilant for these tumors, especially in patients with known bone infarction experiencing new pain.

Keywords:
MRImalignant fibrous histiocytomaosteonecrosisosteosarcomasarcoma

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Area of Science:

  • Orthopedic Oncology
  • Radiology
  • Bone Pathology

Background:

  • Bone sarcomas can rarely arise secondary to osteonecrosis (bone infarction).
  • Characterizing the imaging features of these rare tumors is crucial for timely diagnosis.

Purpose of the Study:

  • To describe the imaging characteristics of infarct-associated bone sarcomas.
  • To identify patterns of osteonecrosis associated with sarcoma development.

Main Methods:

  • Retrospective review of imaging studies for sarcomas in patients with osteonecrosis.
  • Analysis of radiographic, MRI, and scintigraphy findings.
  • Literature review of similar cases.

Main Results:

  • Nine infarct-associated bone sarcomas (seven MFHs, two osteosarcomas) were identified in eight patients.
  • Tumors predominantly occurred in the femur or tibia, often associated with mature osteonecrosis patterns.
  • Imaging revealed cortical penetration and characteristic scintigraphic findings; osteolysis was often initially overlooked.

Conclusions:

  • Infarct-associated bone sarcoma is a rare entity that requires vigilance from radiologists.
  • New pain in patients with known bone infarction should prompt careful evaluation for potential sarcoma development.