Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

1.1K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.1K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.9K
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

3.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.2K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD.

Scientific reports·2020
Same author

Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.

JCI insight·2020
Same author

Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1.

Thorax·2020
Same author

IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids.

Allergy·2019
Same author

Nasal gene expression changes with inhaled corticosteroid treatment in asthma.

Allergy·2019
Same author

Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD.

The European respiratory journal·2019

Related Experiment Video

Updated: Apr 3, 2026

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K

The Asthma-COPD Overlap Syndrome.

Dirkje S Postma, Klaus F Rabe

    The New England Journal of Medicine
    |September 24, 2015
    PubMed
    Summary

    Asthma and chronic obstructive pulmonary disease (COPD) are often distinct, but many patients exhibit features of both. This review explores the asthma-COPD overlap syndrome, highlighting its clinical significance.

    Area of Science:

    • Pulmonology
    • Respiratory Medicine
    • Clinical Medicine

    Background:

    • Traditionally, asthma and chronic obstructive pulmonary disease (COPD) are considered separate respiratory conditions.
    • Growing clinical evidence indicates a significant number of patients present with overlapping symptoms and characteristics of both asthma and COPD.
    • This diagnostic challenge necessitates a deeper understanding of the asthma-COPD overlap syndrome (ACOS).

    Purpose of the Study:

    • To review the current understanding of asthma-COPD overlap syndrome (ACOS).
    • To discuss the clinical implications and diagnostic considerations for patients with ACOS.
    • To synthesize existing literature on the pathophysiology, diagnosis, and management of ACOS.

    Main Methods:

    • Literature review of studies on asthma, COPD, and ACOS.

    More Related Videos

    Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
    04:03

    Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

    Published on: September 27, 2024

    1.7K
    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
    05:34

    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

    Published on: August 18, 2023

    3.8K

    Related Experiment Videos

    Last Updated: Apr 3, 2026

    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
    04:53

    Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

    Published on: October 18, 2024

    1.6K
    Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
    04:03

    Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

    Published on: September 27, 2024

    1.7K
    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders
    05:34

    Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

    Published on: August 18, 2023

    3.8K
  • Analysis of clinical guidelines and research pertaining to respiratory overlap syndromes.
  • Synthesis of data regarding patient demographics, clinical presentation, and treatment outcomes in ACOS.

    • Main Results:

    • Patients with ACOS often exhibit a complex interplay of inflammatory pathways and clinical features from both asthma and COPD.
    • Diagnosis of ACOS can be challenging due to shared symptoms like dyspnea and cough.
    • Identifying ACOS is crucial for tailoring appropriate therapeutic strategies.

    Conclusions:

    • Asthma-COPD overlap syndrome (ACOS) represents a significant clinical entity distinct from isolated asthma or COPD.
    • Further research is needed to refine diagnostic criteria and optimize management protocols for ACOS patients.
    • Recognizing and managing ACOS is essential for improving patient outcomes in obstructive airway diseases.