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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
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Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

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Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...
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Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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MALDI-TOF Mass Spectrometry01:19

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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
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Updated: Apr 3, 2026

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry LA-ICP-MS
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Laser ablation ICP-MS: Application in biomedical research.

Alessandra Sussulini1, Julia Susanne Becker2, Johanna Sabine Becker3

  • 1Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas, P.O. Box 6154, 13083-970, Campinas, SP, Brazil.

Mass Spectrometry Reviews
|September 24, 2015
PubMed
Summary

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) enables detailed elemental mapping in biological tissues. This review covers its applications in metallomics, neurodegenerative diseases, and metalloproteomics.

Keywords:
brain diseasesimaging mass spectrometrylaser ablation inductively coupled plasma mass spectrometrymetallomicsmolecular mass spectrometry

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Area of Science:

  • Bioanalytical Chemistry
  • Mass Spectrometry Imaging
  • Metallomics

Background:

  • Mass spectrometry imaging (MSI) techniques have advanced for analyzing elemental distribution in biological samples.
  • Metallomics focuses on the global analysis of elemental species within cells and tissues.
  • Understanding elemental distribution is crucial for various life science applications.

Purpose of the Study:

  • To review recent biomedical applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging.
  • To discuss LA-ICP-MS as a standalone technique and in combination with molecular MSI.
  • To highlight applications in neurodegenerative diseases, contrast agents, metallodrugs, and metalloproteomics.

Main Methods:

  • Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for elemental distribution mapping.
  • Combination of elemental MSI with molecular MSI for correlative analysis.
  • Gel electrophoresis for metalloproteomics studies.

Main Results:

  • LA-ICP-MS provides qualitative and quantitative elemental distribution maps in biological tissue sections.
  • Correlating elemental and molecular data offers new insights into biological processes.
  • LA-ICP-MS is effective for studying element distribution in diverse tissues like the brain and cartilage.

Conclusions:

  • LA-ICP-MS imaging is a powerful tool for biomedical research.
  • Its integration with molecular MSI enhances analytical capabilities.
  • The technique shows significant promise for advancing our understanding of metallomics and related diseases.