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Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Related Experiment Video

Updated: Apr 3, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
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New Developments in Blastomycosis.

Jeannina A Smith1, Greg Gauthier1

  • 1Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Seminars in Respiratory and Critical Care Medicine
|September 24, 2015
PubMed
Summary

Blastomyces dermatitidis causes blastomycosis, a serious fungal infection endemic to North America. Advances in understanding its pathogenesis, diagnosis, and treatment are improving patient outcomes.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Blastomyces dermatitidis is a thermally dimorphic fungus causing blastomycosis.
  • It is endemic to North America, particularly regions near the Mississippi and Ohio rivers, Great Lakes, and St. Lawrence Seaway.
  • Infections range from asymptomatic to severe sepsis, with a predilection for lungs and skin.

Purpose of the Study:

  • To review recent advances in the understanding of Blastomyces dermatitidis pathogenesis.
  • To highlight updated diagnostic approaches for blastomycosis.
  • To summarize current treatment guidelines for B. dermatitidis infections.

Main Methods:

  • Literature review of recent research on Blastomyces dermatitidis.
  • Analysis of clinical manifestations and epidemiological data.

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  • Summary of the 2008 Infectious Diseases Society of America guidelines.

    • Main Results:

    • B. dermatitidis exhibits dimorphism, existing as mold in the environment and yeast in human tissues.
    • Clinical presentations are diverse, affecting multiple organs but primarily the lungs and skin.
    • Recent research has improved understanding of disease mechanisms and therapeutic strategies.

    Conclusions:

    • Blastomycosis remains a significant public health concern in endemic areas.
    • Continued research is crucial for refining diagnostic tools and treatment regimens.
    • Adherence to updated clinical guidelines is essential for effective management of B. dermatitidis infections.