Related Experiment Video
Updated: Apr 3, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Preventable but neglected: rickets in an informal settlement, Nairobi, Kenya
J K Edwards1, A Thiongó1, R Van den Bergh2
1Médecins Sans Frontières, Nairobi, Kenya.
Insights
Rickets is common in Kibera
Area of Science:
- Pediatrics
- Public Health
- Nutritional Science
Background:
- Rickets is a significant health concern in developing regions.
- Informal settlements present unique challenges for child health.
- Limited sunlight exposure and malnutrition are suspected contributors.
Purpose of the Study:
- To characterize children diagnosed with rickets in Kibera, Kenya.
- To identify demographic and clinical factors associated with rickets.
- To evaluate treatment outcomes and loss to follow-up.
Main Methods:
- Retrospective case review of 82 children diagnosed with rickets.
- Analysis of routine program data on diagnosis and treatment.
- Data collected from Médecins Sans Frontières primary care clinics.
Main Results:
- Rickets affected 57% males, median age 12-14 months.
- 71% had limited sunlight exposure (<=3 hours/week).
- 39% experienced malnutrition; 44% had developmental delays; 40% lost to follow-up.
Conclusions:
- Rickets is prevalent in Kibera's informal settlement.
- Environmental factors likely contribute to rickets.
- Routine vitamin D supplementation is recommended for African well-child care.
Setting:
The primary care clinics of Médecins Sans Frontières within the informal settlement of Kibera, Nairobi, Kenya.
Objective:
To describe the demographic and clinical characteristics of children clinically diagnosed with rickets from September 2012 to October 2013.
Design:
Descriptive retrospective case review of diagnosis and treatment course with vitamin D and calcium using routine programme data.
Results:
Of the 82 children who met the clinical diagnosis of rickets, 57% were male, with a median age of 12 months and 14 months for females. Children with rickets were found to have ⩽3 hours/week sunlight exposure for 71% of the children and malnutrition in 39%. Clinical findings on presentation revealed gross motor developmental delays in 44%. The loss to follow-up rate during treatment was 40%.
Conclusions:
This study found that rickets is a common clinical presentation among children living in the informal settlement of Kibera and that there are likely multiple factors within that environment contributing to this condition. As rickets is a simply and inexpensively preventable non-communicable disease, we suggest that routine vitamin D supplementation be formally recommended by the World Health Organization for well-child care in Africa, especially in the contexts of informal settlements.
More Related Videos
Related Concept Videos
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Specialized Care Centers and Settings-II
Rural health centers are specialized care facilities in remote locations with very few medical personnel. The primary care providers who run the centers are mostly Registered Nurse Practitioners. Here, emergency treatment is provided to critically ill or injured patients before they are transferred to the closest hospital. Fortunately, due to advancement in technology, many rural healthcare facilities and professionals have easy access to diagnostic and treatment...
Acute Kidney Injury I: Introduction
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
PI3K/mTOR/AKT Signaling Pathway

