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Updated: Apr 3, 2026

Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
Published on: February 24, 2026
Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems
Xiao-nan Pang1, Xiao Hong2, Xuan Wei3
11. State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin 300071, China; 2. Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China;
Abstract:
Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Due to its unique physical and chemical properties, lactoferrin has a variety of biological functions including antibacterial, antiviral, anticancer, immunomodulatory activities and regulation of iron absorption. High-yield production of recombinant lactoferrin with biological activity and its application in clinical treatment have been a hot topic for long time. With the development of genetic engineering techniques, various expression systems have been developed to produce recombinant lactoferrin. In this review, we summarize physicochemical characteristics, biological activities, clinical studies and current recombinant expression systems of lactoferrin, in order to provide references for its clinical application.
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