A rare variant of pilomatricoma: pseudobullous pilomatricoma

Area of Science:

• Dermatology
• Pathology
• Oncology

Background:

• Pilomatricoma (PM), also known as calcifying epithelioma of Malherbe, is a benign skin tumor arising from hair follicle matrix cells.
• Various clinical subtypes exist, including familial, perforating, multinodular, exophytic, anetodermic, and giant forms.
• The bullous type of pilomatricoma is rare, occurring in only 3-6% of cases.

Observation:

• This report details a 26-year-old female patient presenting with a rare bullous variant of pilomatricoma.
• The bullous areas were characterized by the presence of lymphatic fluid, leading to the description of 'pseudobulla'.
• Diagnosis was confirmed through comprehensive clinical, radiological, and histopathological examinations.

Findings:

• The patient was diagnosed with pseudobullous pilomatricoma, a subtype characterized by fluid-filled bullae.
• Histopathological analysis confirmed the diagnosis, revealing characteristic features of pilomatricoma with pseudobullous formation.
• The pathogenesis of the bullous appearance in pilomatricoma was reviewed in the context of this case.

Implications:

• This case contributes to the understanding of rare pilomatricoma presentations, specifically the bullous or pseudobullous type.
• It underscores the importance of considering pseudobullous pilomatricoma in the differential diagnosis of bullous skin lesions.
• Further research into the specific mechanisms causing pseudobulla formation in pilomatricoma may refine diagnostic and management strategies.