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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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hPSCreg--the human pluripotent stem cell registry.

Stefanie Seltmann1, Fritz Lekschas1, Robert Müller1

  • 1Berlin-Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin, Berlin, 13353, Germany.

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Summary

The human pluripotent stem cell registry (hPSCreg) offers a centralized, user-friendly platform for accessing vital scientific and ethical data on human embryonic and induced pluripotent stem cell lines. This resource aids researchers by standardizing cell line identification and providing comprehensive information for biomedical applications.

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Area of Science:

  • Biomedical research
  • Stem cell biology
  • Bioinformatics

Background:

  • The number of human embryonic stem cell (hESC) and induced pluripotent stem cell (hiPSC) lines has grown significantly, exceeding 3000 hESC lines.
  • These cell lines have broad potential applications in biomedicine and drug testing.
  • Numerous stem cell banks globally store tens of thousands of cell lines from diverse donors.

Purpose of the Study:

  • To establish a public registry and data portal for human pluripotent stem cell lines (hPSCreg).
  • To provide standardized biological and legal information for hPSC lines.
  • To address the need for unambiguous identification and comparison of hPSC lines across different resources.

Main Methods:

  • Development of a user-friendly, mobile-ready web application for data access.
  • Implementation of automatic generation of unique, standardized names for each registered cell line.
  • Manual validation of scientific and ethical information for hPSC lines.

Main Results:

  • hPSCreg provides a comprehensive database of hESC and hiPSC lines.
  • The registry includes standardized biological data and extensive ethical information on cell sourcing and application conditions.
  • A user-friendly interface allows searching and comparing information from multiple hPSC sources.

Conclusions:

  • hPSCreg is the first global registry offering manually validated scientific and ethical data on hPSC lines.
  • The platform facilitates translational research by providing accessible and standardized information.
  • hPSCreg supports the ethical and efficient use of stem cell resources in research and development.