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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Related Experiment Video

Updated: Apr 3, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

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Published on: April 28, 2022

Screening of differentially expressed genes in pathological scar tissues using expression microarray.

L P Huang¹, Z Mao², L Zhang³

¹Department of Physical Therapy, Chinese PLA General Hospital, Beijing, China.

Genetics and Molecular Research : GMR

|September 25, 2015

Summary

This summary is machine-generated.

Researchers identified significant gene expression differences between pathological scar and normal skin tissues. These findings highlight a complex network of genes and pathways involved in scar development.

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Last Updated: Apr 3, 2026

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Area of Science:

Molecular Biology
Genomics
Dermatology

Background:

Pathological scars result from abnormal wound healing.
Understanding the molecular basis of scar formation is crucial for developing effective treatments.

Purpose of the Study:

To identify differentially expressed genes between pathological scar tissues and normal skin tissues.
To analyze gene ontology and pathway alterations in pathological scars.

Main Methods:

Gene expression microarray analysis was employed to screen for differentially expressed genes.
Gene ontology and pathway analyses were performed on the identified gene expression data.

Main Results:

Significant differences in gene expression were observed between pathological scar and normal foreskin tissues.
Thousands of genes showed differential expression, with 114 genes exhibiting a 20-fold change.

Conclusions:

Pathological scar development is associated with widespread changes in gene expression.
A dynamic network of genes and pathways likely contributes to the formation of pathological scars.